Raloxifene is a tissue-selective estrogen receptor modulator. The effect of estrogen on
cardiovascular disease is mainly dependent on direct actions on the vascular wall involving …

Raloxifene is a selective estrogen receptor modulator (SERM) clinically effective for the
prevention of postmenopausal osteoporosis. Estrogen's effect on cardiovascular diseases is …

Background—Nontranscriptional signaling through estrogen receptors (ERs) is important in
the cardiovascular system. In particular, estrogen stimulates endothelial NO synthase …

Background and Purpose Raloxifene can induce both endothelium‐dependent and‐
independent relaxation in different arteries. However, the underlying mechanisms by which …

Background—It has not been completely clarified whether selective estrogen receptor
modulators (SERMs) such as raloxifene exert vasoprotective effects similar to those of …

We report the modulatory effects of chronic oral LY139481 (raloxifene) on basal release of
nitric oxide (NO) and mRNA levels of endothelial NO synthase (eNOS) in rat thoracic aorta …

Background and purpose: Raloxifene improves cardiovascular function. This study
examines the hypothesis that therapeutic concentrations of raloxifene augment endothelium …

The human estrogen-related receptor α1 (ERRα1) is a member of an orphan receptor family
closely related to the estrogen receptor. It has been demonstrated that estrogen modulates …

Although estrogen is known to activate endothelial nitric oxide synthase (eNOS) in the
vascular endothelium, the molecular mechanism responsible for this effect remains to be …

Background and purpose: Maintaining a delicate balance between the generation of nitric
oxide (NO) and removal of reactive oxygen species (ROS) within the vascular wall is crucial …