The purpose of this review is to provide the reader with an overview of the advances made
in ocular delivery of bioactive molecules by means of chitosan-based nanosystems, and …

Nanoscience and nanotechnology has caused important breakthroughs in different
therapeutic areas. In particular, the application of nanotechnology in ophthalmology has led …

The eye is a very important, yet sensitive organ, presenting complex anatomy. To overcome
its protective mechanisms, with the aim of improving drug delivery, drug encapsulation in …

This paper presents an overview of the potential of chitosan‐based systems for improving
the retention and biodistribution of drugs applied topically onto the eye. Besides its low …

Present limitations in the management of extraocular diseases include the inability to
provide long-term extraocular drug delivery without compromising intraocular structures …

Glaucoma is a degenerative, chronic ocular disease that causes irreversible vision loss. The
major symptom of glaucoma is high intraocular pressure, which happens when the flow of …

Introduction: A major problem in ocular therapeutics with classical formulations is the
maintenance of an effective drug concentration at the site of action for a long period of time …

Purpose. To assess the potential of chitosan (CS) nanoparticles for ocular drug delivery by
investigating their interaction with the ocular mucosa in vivo and also their toxicity in …

The main inconvenience of conventional eye drops is the rapid washout of the drugs due to
nasolacrimal drainage or ophthalmic barriers. The ocular drug bioavailability can be …

purpose. To study the in vitro and in vivo interaction of chitosan nanoparticles (CSNPs), a
new particulate drug carrier, with epithelial cells on the ocular surface. methods. CSNPs …