The successful clinical outcome of the implanted tissue-engineered bone is dependent on
the establishment of a functional vascular network. A gene-enhanced tissue engineering …

Tissue engineering combined with gene therapy represents a promising approach for bone
regeneration. The Hypoxia-inducible factor-1α (HIF-1α) gene is a pivotal regulator of …

Reconstruction of large bone defects still represents a major medical challenge. In recent
years tissue engineering has developed techniques based on adult mesenchymal stem …

Reconstruction of bone defects by tissue engineered substitutes requires coordinated
coupling between osteogenesis and angiogenesis. Basic fibroblast growth factor (bFGF or …

Background and aim Inadequate vascularization is a challenge in bone tissue engineering
because internal cells are prone to necrosis due to a lack of nutrient supply. Rat bone …

The processes of angiogenesis and bone formation are coupled both temporally and
spatially during bone repair. Bone marrow-derived mesenchymal stem cells (BMSCs) have …

Bone is a highly vascularized tissue and efficient bone regeneration requires
neovascularization, especially for critical-sized bone defects. We developed a novel hybrid …

One specific capillary subtype, termed type H vessel, has been found with unique functional
characteristics in coupling angiogenesis with osteogenesis. Researchers have fabricated a …

Currently, most in vitro engineered bone tissues do not contain viable blood vessel systems,
so the vascularization depends on post-implantation angiogenesis from the host, which is …

The presence of insufficient bone volume remains a major clinical problem for dental implant
placement to restore the oral function. Gene-transduced stem cells provide a promising …