Ten years with New Delhi metallo-β-lactamase-1 (NDM-1): from structural insights to inhibitor design

P Linciano, L Cendron, E Gianquinto… - ACS infectious …, 2018 - ACS Publications
The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a
carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized …

Characterization of purified New Delhi metallo-β-lactamase-1

PW Thomas, M Zheng, S Wu, H Guo, D Liu, D Xu… - Biochemistry, 2011 - ACS Publications
New Delhi metallo-β-lactmase-1 (NDM-1) has recently emerged as a global threat because
of its ability to confer resistance to almost all clinically used β-lactam antibiotics, its presence …

New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition

DT King, LJ Worrall, R Gruninger… - Journal of the American …, 2012 - ACS Publications
The β-lactam antibiotics have long been a cornerstone for the treatment of bacterial disease.
Recently, a readily transferable antibiotic resistance factor called the New Delhi metallo-β …

Structure, genetics and worldwide spread of New Delhi metallo-β-lactamase (NDM): a threat to public health

AU Khan, L Maryam, R Zarrilli - BMC microbiology, 2017 - Springer
Background The emergence of carbapenemase producing bacteria, especially New Delhi
metallo-β-lactamase (NDM-1) and its variants, worldwide, has raised amajor public health …

The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis

H Feng, X Liu, S Wang, J Fleming, DC Wang… - Nature …, 2017 - nature.com
New Delhi metallo-β-lactamases (NDMs), the recent additions to metallo-β-lactamases
(MBLs), pose a serious public health threat due to its highly efficient hydrolysis of β-lactam …

Structure of apo-and monometalated forms of NDM-1—a highly potent carbapenem-hydrolyzing metallo-β-lactamase

Y Kim, C Tesar, J Mire, R Jedrzejczak, A Binkowski… - PloS one, 2011 - journals.plos.org
The New Delhi Metallo-β-lactamase (NDM-1) gene makes multiple pathogenic
microorganisms resistant to all known β-lactam antibiotics. The rapid emergence of NDM-1 …

Evolving trends of New Delhi Metallo-betalactamse (NDM) variants: a threat to antimicrobial resistance

N Farhat, AU Khan - Infection, Genetics and Evolution, 2020 - Elsevier
The rapid emergence of carbapenemase producing Gram-negative bacterial strains exhibit
broad-spectrum β-lactam resistance, especially New Delhi metallo-β-lactamase (NDM-1). It …

Molecular basis of NDM-1, a new antibiotic resistance determinant

Z Liang, L Li, Y Wang, L Chen, X Kong, Y Hong, L Lan… - PLoS …, 2011 - journals.plos.org
The New Delhi Metallo-β-lactamase (NDM-1) was first reported in 2009 in a Swedish
patient. A recent study reported that Klebsiella pneumonia NDM-1 positive strain or …

Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

Z Sun, L Hu, B Sankaran, BVV Prasad… - Nature …, 2018 - nature.com
New Delhi metallo-β-lactamase-1 exhibits a broad substrate profile for hydrolysis of the
penicillin, cephalosporin and 'last resort'carbapenems, and thus confers bacterial resistance …

Recent research and development of NDM-1 inhibitors

T Wang, K Xu, L Zhao, R Tong, L Xiong, J Shi - European journal of …, 2021 - Elsevier
Abstract Bacteria carrying New Delhi metallo-β-lactamase-1 (New Delhi metallo-β-
lactamase, NDM-1) resistance gene is a new type of “superbug”, which can hydrolyze …