[HTML][HTML] Bioinformatics prediction of B and T cell epitopes within the spike and nucleocapsid proteins of SARS-CoV2

RM Dawood, MA El-Meguid, GM Salum… - Journal of infection and …, 2021 - Elsevier
Background The striking difference in severity of SARS CoV2 infection among global
population is partly attributed to viral factors. With the spike (S) and nucleocapsid (N) are the …

A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS‐COV‐2 B. 1.617. 1 Variant Spike Protein

VK Srivastava, S Kaushik, G Bhargava… - BioMed Research …, 2021 - Wiley Online Library
Background. B. 1.617. 1, a variant of severe acute respiratory syndrome coronavirus‐2
(SARS‐CoV‐2) causing respiratory illness is responsible for the second wave of COVID‐19 …

Understanding the B and T cell epitopes of spike protein of severe acute respiratory syndrome coronavirus-2: a computational way to predict the immunogens

Y Vashi, V Jagrit, S Kumar - Infection, Genetics and Evolution, 2020 - Elsevier
The 2019 novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak
has caused a large number of deaths, with thousands of confirmed cases worldwide. The …

Energetics and IC50 based epitope screening in SARS CoV-2 (COVID 19) spike protein by immunoinformatic analysis implicating for a suitable vaccine development

A Banerjee, D Santra, S Maiti - Journal of Translational Medicine, 2020 - Springer
Background The recent outbreak by SARS-CoV-2 has generated a chaos in global health
and economy and claimed/infected a large number of lives. Closely resembling with SARS …

Bioinformatic analysis of B-and T-cell epitopes from SARS-CoV-2 structural proteins and their potential cross-reactivity with emerging variants and other human …

DL Pacheco-Olvera, S Saint Remy-Hernández… - Archives of Medical …, 2022 - Elsevier
Background The mutations in SARS-CoV-2 variants of concern (VOC) facilitate the virus'
escape from the neutralizing antibodies induced by vaccines. However, the protection from …

Computational perspectives revealed prospective vaccine candidates from five structural proteins of novel SARS corona virus 2019 (SARS-CoV-2)

R Anand, S Biswal, R Bhatt, BN Tiwary - PeerJ, 2020 - peerj.com
Background The present pandemic COVID-19 is caused by SARS-CoV-2, a single-stranded
positive-sense RNA virus from the Coronaviridae family. Due to a lack of antiviral drugs …

Immunoinformatics approach to understand molecular interaction between multi-epitopic regions of SARS-CoV-2 spike-protein with TLR4/MD-2 complex

M Bhattacharya, AR Sharma, B Mallick… - Infection, Genetics and …, 2020 - Elsevier
Abstract Background The coronavirus (CoV) spike (S) protein is critical for receptor binding,
membrane fusion and internalization of the virus into the human cells. We have tried to …

Immunoinformatic analysis of structural and epitope variations in the spike and Orf8 proteins of SARS‐CoV‐2/B. 1.1. 7

M Hussain, S Shabbir, A Amanullah… - Journal of medical …, 2021 - Wiley Online Library
A newly emerged strain of SARS‐CoV‐2 of B. 1.1. 7 lineage has caused a significant surge
in the SARS‐CoV‐2 infections in the UK. In this study, changes in the epitopes of spike and …

T and B cell Epitope analysis of SARS‐CoV‐2 S protein based on immunoinformatics and experimental research

Z Chen, P Ruan, L Wang, X Nie, X Ma… - Journal of cellular and …, 2021 - Wiley Online Library
COVID‐19 caused by SARS‐CoV‐2 is pandemic with a severe morbidity and mortality rate
across the world. Despite the race for effective vaccine and drug against further expansion …

The Key Site Variation and Immune Challenges in SARS-CoV-2 Evolution

Y Liu, Q Ye - Vaccines, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) is a worldwide public health and economic threat,
and virus variation amplifies the difficulty in epidemic prevention and control. The structure of …