Microglia in the neuroinflammatory pathogenesis of Alzheimer's disease and related therapeutic targets

Y Cai, J Liu, B Wang, M Sun, H Yang - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease

D Singh - Journal of neuroinflammation, 2022 - Springer
Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

The effects of microglia-associated neuroinflammation on Alzheimer's disease

C Wang, S Zong, X Cui, X Wang, S Wu… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

Microglia in Alzheimer's disease

Y Li, MS Tan, T Jiang, L Tan - BioMed research international, 2014 - Wiley Online Library
Alzheimer's disease (AD) is a familiar neurodegenerative disease in the elderly. In this
paper, we will review current viewpoints of microglial activation, inflammatory regulatory …

[HTML][HTML] Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease

WY Wang, MS Tan, JT Yu, L Tan - Annals of translational medicine, 2015 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain, which is
characterized by the formation of extracellular amyloid plaques (or senile plaques) and …

Microglia in Alzheimer's disease: a target for therapeutic intervention

G Zhang, Z Wang, H Hu, M Zhao, L Sun - Frontiers in Cellular …, 2021 - frontiersin.org
Alzheimer's disease (AD) is one of the most common types of age-related dementia
worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary …

Glial cell-mediated neuroinflammation in Alzheimer's disease

NF Al-Ghraiybah, J Wang, AE Alkhalifa… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder; it is the most
common cause of dementia and has no treatment. It is characterized by two pathological …

Alzheimer's disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation

S Anwar, S Rivest - Expert opinion on therapeutic targets, 2020 - Taylor & Francis
Introduction: Despite the revolutionary progress in neurodegenerative disease research,
there is no cure for Alzheimer's disease (AD). This is a chronic progressive …

Microglia and Alzheimer's disease

S Merighi, M Nigro, A Travagli, S Gessi - International Journal of …, 2022 - mdpi.com
There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …

Microglia function in Alzheimer's disease

E Solito, M Sastre - Frontiers in pharmacology, 2012 - frontiersin.org
Contrary to early views, we now know that systemic inflammatory/immune responses
transmit to the brain. The microglia, the resident “macrophages” of the brain's innate immune …