From biomarkers to therapeutic targets—the promises and perils of long non-coding RNAs in cancer

T Gutschner, G Richtig, M Haemmerle… - Cancer and Metastasis …, 2018 - Springer
Biomarker-driven personalized cancer therapy is a field of growing interest, and several
molecular tests have been developed to detect biomarkers that predict, eg, response of …

Long non-coding RNAs in cancer: implications for diagnosis, prognosis, and therapy

Y Qian, L Shi, Z Luo - Frontiers in medicine, 2020 - frontiersin.org
Long non-coding RNAs (lncRNAs) are major components of cellular transcripts that are
arising as important players in various biological pathways. They have received extensive …

Long noncoding RNAs in cancer: from discovery to therapeutic targets

R Choudhari, MJ Sedano, AL Harrison… - Advances in clinical …, 2020 - Elsevier
Long noncoding RNAs (lncRNAs) have recently gained considerable attention as key
players in biological regulation; however, the mechanisms by which lncRNAs govern …

Therapeutic targeting of long non-coding RNAs in cancer

G Arun, SD Diermeier, DL Spector - Trends in molecular medicine, 2018 - cell.com
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …

Long noncoding RNAs in cancer: mechanisms of action and technological advancements

N Bartonicek, JLV Maag, ME Dinger - Molecular cancer, 2016 - Springer
The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to
being defined as a category of genetic elements, leaving its mark on the field of cancer …

Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers

N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Keep your eyes peeled for long noncoding RNAs: Explaining their boundless role in cancer metastasis, drug resistance, and clinical application

GK Barik, O Sahay, A Behera, D Naik… - Biochimica et Biophysica …, 2021 - Elsevier
Cancer metastasis and drug resistance are two major obstacles in the treatment of cancer
and therefore, the leading cause of cancer-associated mortalities worldwide. Hence, an in …

Long noncoding RNAs in cancer metastasis

SJ Liu, HX Dang, DA Lim, FY Feng… - Nature Reviews Cancer, 2021 - nature.com
Metastasis is a major contributor to cancer-associated deaths. It is characterized by a
multistep process that occurs through the acquisition of molecular and phenotypic changes …

Diagnostic, prognostic and therapeutic potential of long noncoding RNAs in cancer

MB Khawar, SE Hamid, T Jan, MH Abbasi… - Molecular Biology …, 2022 - Springer
Long noncoding RNAs (lncRNAs) are longer than 200 nucleotides in length and undergo
splicing, capping, polyadenylation, and editing just like mRNA. Evidence is growing that they …

Perspectives of long non-coding RNAs in cancer

AKDM Rao, T Rajkumar, S Mani - Molecular biology reports, 2017 - Springer
A recent advance in transcriptomics has spawned the 'Decade of non-coding RNAs' by
potentiating the growing numbers of long non-coding RNA in cancer. LncRNA involvement …