Introduction: The incidence of sepsis, the systemic inflammatory response of the host to an
infectious insult, has steadily increased over past decades. This trend is expected to …

Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the
disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving …

Introduction: The last five years, there have been considerable changes in our perception on
the pathogenesis of sepsis. This review aims to summarize the current progress of the last …

Sepsis is a syndrome which is defined as a dysregulated host response to infection leading
to organ failure. Since it remains one of the leading causes of mortality worldwide, numerous …

D espite recent improvements in intensive care monitoring, diagnostic techniques, and
therapies, sepsis remains common among the critically ill. Moreover, related mortality rates …

Sepsis represents a major global health concern and is one of the most feared
complications for hospitalized patients, being the cause, directly or indirectly, of about half of …

Sepsis and septic shock continue to be a major cause of morbidity and mortality. Despite
numerous advances in the supportive care of patients with sepsis, the overall mortality has …

Introduction: Despite considerable advances in our understanding of how sepsis develops
and multiple clinical trials of potential therapies, no new pharmacologic agent has been …

Despite multiple trials of potential therapies for sepsis, no strategies have yet been
persistently shown to have beneficial effects on outcomes. The main reason for the …

Sepsis continues to escape a precise diagnostic definition. The most recent consensus
definition, termed Sepsis-3, highlights the importance of the maladaptive and potentially life …