Nonmammalian vertebrates regenerate lost sensory hair cells by means of asymmetric
division of supporting cells. Inner ear or lateral line supporting cells in birds, amphibians …

The mammalian inner ear has very limited ability to regenerate lost sensory hair cells. This
deficiency becomes apparent when hair cell loss leads to hearing loss as a result of either …

The adult mammalian cochlea lacks regenerative capacity, which is the main reason for the
permanence of hearing loss. Vestibular organs, in contrast, replace a small number of lost …

Loss of hair cells in mammals including human beings causes permanent hearing loss
because the cochlea cannot regenerate hair cells spontaneously. Here we show that the …

Stem cells in the nervous system have some capacity to restore damaged tissue.
Proliferation of stem cells endows them with self-renewal ability and accounts for in vitro …

Genetic, noise-and drug-induced loss of hair cells in the mouse and human cochlea leads to
permanent hearing loss due to lack of regeneration of hair cells, which may be due to …

Cochlear hair cells are a terminally differentiated cell population that is crucial for hearing.
Although recent work suggests that there are hair cell progenitors in postnatal mammalian …

Stem cells in various mammalian organs retain the capacity to renew themselves and may
be able to restore damaged tissue. Their existence has been proven by genetic tracer …

Loss of inner ear hair cells leads to incurable balance and hearing disorders because these
sensory cells do not effectively regenerate in humans. A potential starting point for therapy …

Hair cells and supporting cells of the mammalian cochlea terminally differentiate during
development. Recent in vitro evidence suggests the presence of hair cell progenitors in the …