Over the past 10 years evidence has been accumulating that antitumour agents induce
apoptosis in cancer cells and that abnormalities in apoptosis signaling pathways often occur …

Resistance towards apoptosis is a key factor for the survival of a malignant cell. Cancer
results if there is too little apoptosis and cells grow faster and live longer than normal cells. In …

Cancer is a leading cause of death in human beings. Surgery, chemotherapy, radiotherapy,
immunotherapy, and biologically targeted therapy are common modalities for cancer …

Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, eg
chemotherapy, γ-irradiation, immunotherapy or suicide gene therapy, is predominantly …

Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

Major advances have been made in our understanding of the regulation of the molecular
machinery of apoptosis in vitro. Molecules linking proliferation and apoptosis in healthy cells …

Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to
expand even in a stressful environment. Cells resistant to apoptosis are also assumed to be …

The therapeutic goal in cancer treatment is to trigger tumor-selective cell death. Since many
antineoplastic agents induce an apoptotic type of death in susceptible cells, it is likely that …

Apoptosis is a genetically controlled and evolutionarily conserved form of cell death of
critical importance for normal embryonic development and for the maintenance of tissue …

Apoptosis is a tightly regulated cell suicide program that plays an essential role in the
maintenance of tissue homeostasis by eliminating unnecessary or harmful cells. Defects in …