[HTML][HTML] Choosing immunomodulating therapies for the treatment of COVID-19: recommendations based on placebo-controlled trial evidence
Background Immunomodulatory therapy has been extensively studied in randomized
clinical trials for the treatment of patients hospitalized for COVID-19 with inconsistent …
clinical trials for the treatment of patients hospitalized for COVID-19 with inconsistent …
Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients-mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19–Repurposed Drugs …
S Kulkarni, M Fisk, M Kostapanos, E Banham-Hall… - Trials, 2020 - Springer
Objectives To determine if a specific immunomodulatory intervention reduces progression of
COVID-19-related disease to organ failure or death, compared to standard of care (SoC) …
COVID-19-related disease to organ failure or death, compared to standard of care (SoC) …
Baricitinib versus tocilizumab in critically ill COVID‐19 patients: A retrospective cohort study
Objectives The immunomodulators tocilizumab and baricitinib improve outcomes in severely
ill patients with coronavirus disease 2019 (COVID‐19); however, comparative analyses of …
ill patients with coronavirus disease 2019 (COVID‐19); however, comparative analyses of …
[HTML][HTML] Triple immune modulator therapy for aberrant hyperinflammatory responses in severe COVID-19
A dysregulated hyperinflammatory response is a key pathogenesis of severe COVID-19, but
optimal immune modulator treatment has not been established. To evaluate the clinical …
optimal immune modulator treatment has not been established. To evaluate the clinical …
[HTML][HTML] Immunomodulation and COVID-19: Is There a Winning Combination?
S Samavedam - Indian Journal of Critical Care Medicine: Peer …, 2020 - ncbi.nlm.nih.gov
A bstract Coronavirus disease-2019 (COVID-19) has been testing the boundaries of science
on several fronts. Pharmacotherapy has seen the highs of several drugs being tried as the …
on several fronts. Pharmacotherapy has seen the highs of several drugs being tried as the …
[HTML][HTML] Cytokine storm and immunomodulation in COVID-19
P Rangappa - Indian Journal of Critical Care Medicine: Peer …, 2021 - ncbi.nlm.nih.gov
ABSTRACT COVID-19 has become a major pandemic in recent times. The exact
pathophysiology and understanding of cytokine storm and immunomodulation are evolving …
pathophysiology and understanding of cytokine storm and immunomodulation are evolving …
[HTML][HTML] Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives The objective of this study was to estimate the association between tocilizumab
or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 …
or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 …
[HTML][HTML] Role of tocilizumab in the treatment of COVID-19 patients with cytokine storm: a case series
A Basnet, MR Shrestha, R Thapa… - JNMA: Journal of the …, 2022 - ncbi.nlm.nih.gov
The in-hospital mortality in patients with COVID-19 could be correlated with severe acute
respiratory syndrome coronavirus-2 induced hyper-inflammation, which is attributed to an …
respiratory syndrome coronavirus-2 induced hyper-inflammation, which is attributed to an …
[HTML][HTML] Tocilizumab, netakimab, and baricitinib in patients with mild-to-moderate COVID-19: An observational study
EA Bryushkova, VD Skatova, ZY Mutovina… - PloS one, 2022 - journals.plos.org
Objective The aim of the study was to assess inflammatory markers and clinical outcomes in
adult patients admitted to hospital with mild-to-moderate COVID-19 and treated with a …
adult patients admitted to hospital with mild-to-moderate COVID-19 and treated with a …
[HTML][HTML] Efficacy and safety of baricitinib and tocilizumab in hospitalized patients with COVID-19: a comparison using systematic review and meta-analysis
Objective: This review was performed to compare the efficacy and safety among hospitalized
patients with COVID-19 who received baricitinib and those who received tocilizumab …
patients with COVID-19 who received baricitinib and those who received tocilizumab …