Plasma proteomics identify biomarkers and pathogenesis of COVID-19

T Shu, W Ning, D Wu, J Xu, Q Han, M Huang, X Zou… - Immunity, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) pandemic is a global public health
crisis. However, little is known about the pathogenesis and biomarkers of COVID-19. Here …

Longitudinal plasma proteomics analysis reveals novel candidate biomarkers in acute COVID-19

Y Mohammed, DR Goodlett, MP Cheng… - Journal of proteome …, 2022 - ACS Publications
The host response to COVID-19 pathophysiology over the first few days of infection remains
largely unclear, especially the mechanisms in the blood compartment. We report on a …

Characterization by quantitative serum proteomics of immune-related prognostic biomarkers for COVID-19 symptomatology

M Villar, JM Urra, FJ Rodríguez-del-Río… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic caused by SARS-CoV-2 challenges the understanding of factors
affecting disease progression and severity. The identification of prognostic biomarkers and …

Serum protein profiling reveals a landscape of inflammation and immune signaling in early-stage COVID-19 infection

X Hou, X Zhang, X Wu, M Lu, D Wang, M Xu… - Molecular & Cellular …, 2020 - ASBMB
Coronavirus disease 2019 (COVID-19) is a highly contagious infection and threating the
human lives in the world. The elevation of cytokines in blood is crucial to induce cytokine …

Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

MAY Al-Nesf, HB Abdesselem, I Bensmail… - Nature …, 2022 - nature.com
COVID-19 complications still present a huge burden on healthcare systems and warrant
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia

LM Palma Medina, H Babačić, M Dzidic, Å Parke… - Respiratory …, 2023 - Springer
Background COVID-19 remains a major public health challenge, requiring the development
of tools to improve diagnosis and inform therapeutic decisions. As dysregulated …

Proteomic blood profiling in mild, severe and critical COVID-19 patients

H Patel, NJ Ashton, RJB Dobson, LM Andersson… - Scientific reports, 2021 - nature.com
The recent SARS-CoV-2 pandemic manifests itself as a mild respiratory tract infection in
most individuals, leading to COVID-19 disease. However, in some infected individuals, this …

In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients

J Park, H Kim, SY Kim, Y Kim, JS Lee, K Dan… - Scientific reports, 2020 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over forty
million patients worldwide. Although most coronavirus disease 2019 (COVID-19) patients …

High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion

PE Geyer, FM Arend, S Doll, ML Louiset… - EMBO molecular …, 2021 - embopress.org
A deeper understanding of COVID‐19 on human molecular pathophysiology is urgently
needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here …

Identification of serum prognostic biomarkers of severe COVID-19 using a quantitative proteomic approach

Y Kimura, Y Nakai, J Shin, M Hara, Y Takeda, S Kubo… - Scientific reports, 2021 - nature.com
The COVID-19 pandemic is an unprecedented threat to humanity that has provoked global
health concerns. Since the etiopathogenesis of this illness is not fully characterized, the …