Viral infection-induced activation of inflammasome complexes has both positive and
negative effects on the host. Proper activation of inflammasome complexes induces down …

Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of
proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers activation
of the NLRP3 inflammasome, which promotes inflammation and aggravates severe COVID …

Despite the initial success of some drugs and vaccines targeting COVID-19, understanding
the mechanism underlying SARS-CoV-2 disease pathogenesis remains crucial for the …

Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …

Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We
report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most …

Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …