An immune response involves the action of all types of macrophages, classically activated
subtype (M1) in the early inflammatory phase and regulatory and wound-healing subtypes …

Macrophages play an important role in tissue repair, regeneration, and the ability of
biomaterials to mediate these processes. Macrophages are highly plastic cells that exhibit …

Endogenous regeneration aims to rebuild and reinstate tissue function through enlisting
natural self-repairing processes. Promoting endogenous regeneration by reducing tissue …

Successful wound healing is a process that has three overlying phases: inflammatory,
proliferative and remodeling. Chronic wounds are characterized by a perpetuated …

Musculoskeletal disorders are common in clinical practice. Repairing critical-sized defects in
musculoskeletal systems remains a challenge for researchers and surgeons, requiring the …

Macrophage immunotherapy is an emerging treatment strategy that modulates the immune
system to promote wound healing. The functionality and regeneration of tissue depend on …

Monocytes and macrophages play a critical role in tissue development, homeostasis, and
injury repair. These innate immune cells participate in guiding vascular remodeling …

The understanding of macrophages and their pathophysiological role has dramatically
changed within the last decades. Macrophages represent a very interesting cell type with …

Although most tissue types are capable of some form of self-repair and regeneration, injuries
that are larger than a critical threshold or those occurring in the setting of certain diseases …

The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …