Autoimmune and inflammatory diseases are common and diverse, and they can affect
nearly any organ system. Much of the pathogenesis of these diseases is related to …

Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a
consequence they play pivotal roles in the patho-physiology of many diseases including …

The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

The Janus kinases (JAKs) are a family of intracellular tyrosine kinases that play an essential
role in the signaling of numerous cytokines that have been implicated in the pathogenesis of …

The four Janus kinase (JAK) proteins and the seven Signal Transducers of Activated
Transcription (STAT) mediate intracellular signal transduction downstream of cytokine …

Cytokines are major drivers of autoimmunity, and biologic agents targeting cytokines have
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …

Abstract The European Journal of Immunology was launched 50 years ago, coinciding with
the discovery of many cytokines and growth factors and the emergence of an entirely new …

Janus kinase (JAK) inhibitors (jakinibs) that target downstream signalling by a large range of
cytokines are effective in treating autoimmune and rheumatic diseases. Newer jakinibs that …

The four Janus kinase (JAK) proteins and seven signal transducer and activator of
transcription (STAT) transcription factors mediate intracellular signal transduction …

Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting
cytokines and cytokine receptors with biologics has revolutionized the treatment of many of …