Doxorubicin (DOX) is the most effective and frequently used anticancer drug. This work
aimed to study the protective role of silymarin (SIL) against DOX induced cardiotoxicity. Forty …

Background: despite its vast utility in clinical oncology, the use of doxorubicin is limited by a
potentially fatal cardiomyopathy and congestive heart failure. Free radical formation and …

Silymarin is a complex of five major compounds, and silibinin is the most biologically active
component of the complex. The aim of this study was to investigate, evaluate and confirm the …

Purpose Although doxorubicin chemotherapy is commonly applied for treating different
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …

We investigated the potential protective effects of silymarin (SLY) on doxorubicin (DOX)
induced chronic cardiotoxicity in mice. We used 30 male BALB/c mice assigned randomly to …

Abstract Context: Doxorubicin (Dox) is one of the most active chemotherapeutic agents used
to treat various types of cancers. Its clinical utility is compromised due to fatal cardiac toxicity …

Objectives The aim of the present study was to investigate the effect of silymarin on
doxorubicin-induced toxicity to the rat kidney, heart, and liver. Materials and methods A …

Introduction Cyclophosphamide (CP) is a potent anticancer agent; its clinical use is limited
due to its marked cardiotoxicity. Aim The present study was aimed at evaluating the …

In the present study it was aimed to evaluate the combined effect of simvastatin (SIM) and
hydro alcoholic seeds extract of Lagenaria siceraria (HLSSE) in doxorubicin (DOX) induced …

Aim: In this article, we evaluated the possible cardiac protective effects of silymarin on
valproic acid-induced heart injury by histological and biochemical parameters in rat heart …