Patients with schizophrenia experience cognitive dysfunction and negative symptoms that
do not respond to current drug treatments. Historical evidence is consistent with the …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

Schizophrenia is a severe neuropsychiatric syndrome with psychotic behavioral
abnormalities and marked cognitive deficits. It is widely accepted that genetic and …

Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …

Schizophrenia alters basic brain processes of perception, emotion, and judgment to cause
hallucinations, delusions, thought disorder, and cognitive deficits. Unlike neurodegeneration …

Schizophrenia is associated with alterations in sensory, motor, and cognitive functions that
emerge before psychosis onset; identifying pathogenic processes that can account for this …

The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Schizophrenia is a chronic, severe, and disabling brain disorder, with an estimated lifetime
prevalence of 0.7%. Despite its relatively low prevalence, the onset of schizophrenia usually …

Schizophrenia is a chronic and severe mental illness which frequently leads to substantial
lifelong disability. The past five years have seen major progress in our understanding of the …

Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …