Tenogenic differentiation of stem cells for tendon repair—what is the current evidence?

PPY Lui, YF Rui, M Ni, KM Chan - Journal of tissue engineering …, 2011 - Wiley Online Library
Tendon/ligament injuries are very common in sports and other rigorous activities. Tendons
regenerate and repair slowly and inefficiently in vivo after injury. The limited ability of tendon …

[HTML][HTML] Current concepts on tenogenic differentiation and clinical applications

Y Liu, CW Suen, J Zhang, G Li - Journal of orthopaedic translation, 2017 - Elsevier
Tendon is a tissue that transmits force from muscle to bone. Chronic or acute tendon injuries
are very common, and are always accompanied by pain and a limited range of motion in …

Tendon tissue engineering: Current progress towards an optimized tenogenic differentiation protocol for human stem cells

I Donderwinkel, RS Tuan, NR Cameron, JE Frith - Acta Biomaterialia, 2022 - Elsevier
Tendons are integral to our daily lives by allowing movement and locomotion but are
frequently injured, leading to patient discomfort and impaired mobility. Current clinical …

Multi-differentiation potential is necessary for optimal tenogenesis of tendon stem cells

I Rajpar, JG Barrett - Stem cell research & therapy, 2020 - Springer
Background Tendon injury is a significant clinical problem due to poor healing and a high
reinjury rate; successful treatment is limited by our poor understanding of endogenous …

Directed differentiation and paracrine mechanisms of mesenchymal stem cells: potential implications for tendon repair and regeneration

B Zhang, Q Luo, A Halim, Y Ju… - Current Stem Cell …, 2017 - ingentaconnect.com
Background: Tendon is composed of connective tissue, is able to retract with high tensile
force, and plays a significant role in musculoskeletal motion. However, inappropriate …

Stepwise differentiation of mesenchymal stem cells augments tendon-like tissue formation and defect repair in vivo

Z Yin, J Guo, T Wu, X Chen, L Xu, S Lin… - Stem cells …, 2016 - academic.oup.com
Tendon injuries are common and present a clinical challenge, as they often respond poorly
to treatment and result in long-term functional impairment. Inferior tendon healing responses …

A comparison of the stem cell characteristics of murine tenocytes and tendon-derived stem cells

KJ Lee, PD Clegg, EJ Comerford… - BMC Musculoskeletal …, 2018 - Springer
Tendon is a commonly injured soft musculoskeletal tissue, however, poor healing potential
and ineffective treatment strategies result in persistent injuries and tissue that is unable to …

The use of cocultured mesenchymal stem cells with tendon-derived stem cells as a better cell source for tendon repair

T Wu, Y Liu, B Wang, Y Sun, J Xu… - … Engineering Part A, 2016 - liebertpub.com
The management of tendon tissue injury presents a significant clinical challenge due to the
unique properties of tendons. Cell-based therapy provides a new alternative for …

Tendon-derived stem cells undergo spontaneous tenogenic differentiation

J Guo, KM Chan, JF Zhang, G Li - Experimental Cell Research, 2016 - Elsevier
Tendon-derived stem cell (TDSC) is a subpopulation of residing stem cells within the intact
tendon tissues, with the capacities of self-renewal, clonogenicity, and three-lineage …

Tendon repair through stem cell intervention: cellular and molecular approaches

R Bullough, T Finnigan, A Kay, N Maffulli… - Disability and …, 2008 - Taylor & Francis
Tendon injuries are common in either the workplace or sport activities, with some 3 to 5
million tendon and ligament injuries occurring annually worldwide. Management of tendon …