Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial

AC Schaub, E Schneider… - Translational …, 2022 - nature.com
A promising new treatment approach for major depressive disorder (MDD) targets the
microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions …

Probiotics for the treatment of depressive symptoms: an anti-inflammatory mechanism?

C Park, E Brietzke, JD Rosenblat, N Musial… - Brain, Behavior, and …, 2018 - Elsevier
During the past decade, there has been renewed interest in the relationship between brain-
based disorders, the gut microbiota, and the possible beneficial effects of probiotics …

[HTML][HTML] The efficacy, safety, and tolerability of probiotics on depression: clinical results from an open-label pilot study

CJK Wallace, RV Milev - Frontiers in psychiatry, 2021 - frontiersin.org
Background: A growing body of research has shown that consumption of probiotics can
improve symptoms associated with mood and anxiety disorders through activity of the gut …

Effect of short-term, high-dose probiotic supplementation on cognition, related brain functions and BDNF in patients with depression: a secondary analysis of a …

E Schneider, JPK Doll, N Schweinfurth… - Journal of Psychiatry and …, 2023 - jpn.ca
Background: In major depressive disorder (MDD), cognitive dysfunctions strongly contribute
to functional impairments but are barely addressed in current therapies. Novel treatment …

[HTML][HTML] Gut microbiota and pathophysiology of depressive disorder

H Kunugi - Annals of Nutrition and Metabolism, 2021 - karger.com
Background: Accumulating evidence has suggested that the bi-directional communication
pathway, the microbiota-gut-brain axis, plays an important role in the pathophysiology of …

Acceptability, tolerability, and estimates of putative treatment effects of probiotics as adjunctive treatment in patients with depression: a randomized clinical trial

VL Nikolova, AJ Cleare, AH Young, JM Stone - JAMA psychiatry, 2023 - jamanetwork.com
Importance The microbiota-gut-brain axis is a promising target for novel treatments for mood
disorders, such as probiotics. However, few clinical trials have been conducted, and further …

A microbial-based approach to mental health: the potential of probiotics in the treatment of depression

D Johnson, V Letchumanan, CC Thum… - Nutrients, 2023 - mdpi.com
Probiotics are currently the subject of intensive research pursuits and also represent a multi-
billion-dollar global industry given their vast potential to improve human health. In addition …

The gut microbiome in depression and potential benefit of prebiotics, probiotics and synbiotics: a systematic review of clinical trials and observational studies

SR Alli, I Gorbovskaya, JCW Liu, NJ Kolla… - International journal of …, 2022 - mdpi.com
An emerging body of literature demonstrates differences in the gut microbiome (GMB) of
patients with major depressive disorder (MDD) compared to healthy controls (HC), as well …

Effect of probiotic interventions on depressive symptoms: A narrative review evaluating systematic reviews

I Nadeem, MZ Rahman… - Psychiatry and …, 2019 - Wiley Online Library
Depression is one of the most prevalent mental illnesses and is often associated with
various other medical disorders. Since the 1980s, the primary pharmacological treatment …

Gut feeling: Randomized controlled trials of probiotics for the treatment of clinical depression: Systematic review and meta-analysis

V Nikolova, SY Zaidi, AH Young… - Therapeutic …, 2019 - journals.sagepub.com
Background: Recently the gut microbiota has attracted significant interest in psychiatric
research due to the observed bidirectional gut–brain communication. A growing body of …