Cancer stemness is associated with high malignancy and low differentiation, as well as
therapeutic resistance of tumors including pancreatic ductal adenocarcinoma (PDAC) …

Pancreatic adenocarcinoma (PDAC) claims more than 90% of the patients diagnosed with
the disease owing to its aggressive biology that is manifested by high rate of tumor …

SOX2 (Sex-determining region Y (SRY)-Box2) has important functions during embryonic
development and is involved in cancer stem cell (CSC) maintenance, in which it impairs cell …

Simple Summary Pancreatic cancers are lethal types of cancer. A majority of patients
progress to an advanced and metastatic disease, which remains a major clinical problem …

Pancreatic ductal adenocarcinoma (PDAC) is a highly deadly malignancy. Expression of the
stem cell transcription factor SOX2 increases during progression of PDAC. Knockdown of …

Pancreatic cancer (PC) is difficult to defeat due to mechanism (s) driving metastasis and
drug resistance. Cancer stemness is a major challenging phenomenon associated with PC …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic tumor, is a
highly aggressive human cancer with the lowest five-year survival rate of any human …

All mature pancreatic cell types arise from organ-specific multipotent progenitor cells.
Although previous studies have identified cell-intrinsic and-extrinsic cues for progenitor cell …

Recent studies indicate that cancer stem cells (CSCs) exist in most hematological and solid
tumors. CSCs are characterized by their ability to self-renew and their capacity to …

Pancreatic cancer is the fourth leading cause of cancer-related mortality in the world.
Pancreatic cancer can be localized, locally advanced, or metastatic. The median 1-and 5 …