Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of
adults. While large-scale genetics studies have identified genomic regions associated with …

It is widely thought that alleles that influence susceptibility to common diseases, including
schizophrenia, will frequently do so through effects on gene expression. As only a small …

Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

Recent genome-wide association studies (GWAS) have identified multiple risk loci that show
strong associations with schizophrenia. However, pinpointing the potential causal genes at …

Human neuropsychiatric disorders are associated with genetic and environmental factors
affecting the brain, which has been subjected to strong evolutionary pressures resulting in …

Schizophrenia is a multifactorial disorder, the genetic architecture of which remains unclear.
Although many studies have examined the etiology of schizophrenia, the gene sets that …

Over the last 8 years the Psychiatric Genomics Consortium (PGC; http://pgc. unc. edu) has
fundamentally changed the landscape for psychiatric genetics research. This has been …

Background Genome-wide association studies have identified several common risk loci for
schizophrenia (SCZ). In parallel, neuroimaging studies have shown consistent findings of …

Unlike the typical analysis of single markers in genome-wide association studies (GWAS),
we incorporated Gene Set Enrichment Analysis (GSEA) and hypergeometric test and …

Genome-wide association studies have implicated thousands of noncoding variants across
common human phenotypes. However, they cannot directly inform the cellular context in …