Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that
belong to the Cys-loop receptor superfamily. These receptors are allosteric proteins that …

It has been almost 20 years since the discovery and crystallization of a structural surrogate,
the Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP), comprising the …

Rapid neurotransmission is mediated through a superfamily of Cys-loop receptors that
includes the nicotinic acetylcholine (nAChR), γ-aminobutyric acid (GABAA), serotonin (5 …

The nicotinic acetylcholine (ACh) receptor (nAChR) plays a crucial role in excitatory
neurotransmission and is an important target for drugs and insecticides. Diverse nAChR …

Modulation of Cys loop receptor ion channels is a proven drug discovery strategy, but many
underlying mechanisms of the mode of action are poorly understood. We report the x-ray …

Nicotinic acetylcholine receptors (nAChRs) are in the superfamily of Cys‐loop ligand‐gated
ion channels, and are pentameric assemblies of five subunits, with each subunit arranged …

Nicotinic acetylcholine receptors (nAChRs) are well-characterized allosteric transmembrane
proteins involved in the rapid gating of ions elicited by ACh. These receptors belong to the …

The crystal structure of acetylcholine-binding protein (AChBP) from the mollusk Lymnaea
stagnalis is the established model for the ligand binding domains of the ligand-gated ion …

Nicotinic acetylcholine receptors (nAChRs) are in the superfamily of cys‐loop receptors, and
are widely expressed in the nervous system where they participate in a variety of …

Nicotinic acetylcholine receptors (nAChRs) display a broad variety of subtypes, which in turn
present a complex subcellular and regional expression pattern in the brain, as well as a …