Genome-wide association study of hematological and biochemical traits in a Japanese population

Y Kamatani, K Matsuda, Y Okada, M Kubo, N Hosono… - Nature …, 2010 - nature.com
We report genome-wide association studies for hematological and biochemical traits from∼
14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 …

Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans

KS Lo, JG Wilson, LA Lange, AR Folsom, G Galarneau… - Human genetics, 2011 - Springer
Red blood cell, white blood cell, and platelet measures, including their count, sub-type and
volume, are important diagnostic and prognostic clinical parameters for several human …

A cross-population atlas of genetic associations for 220 human phenotypes

S Sakaue, M Kanai, Y Tanigawa, J Karjalainen… - Nature …, 2021 - nature.com
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non …

Genome‐wide association studies and the genetic dissection of complex traits

P Sebastiani, N Timofeev, DA Dworkis… - American journal of …, 2009 - Wiley Online Library
The availability of affordable high throughput technology for parallel genotyping has opened
the field of genetics to genome‐wide association studies (GWAS), and in the last few years …

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

K Ishigaki, M Akiyama, M Kanai, A Takahashi… - Nature …, 2020 - nature.com
The overwhelming majority of participants in current genetic studies are of European
ancestry. To elucidate disease biology in the East Asian population, we conducted a …

[PDF][PDF] Joint analysis of functional genomic data and genome-wide association studies of 18 human traits

JK Pickrell - The American Journal of Human Genetics, 2014 - cell.com
Annotations of gene structures and regulatory elements can inform genome-wide
association studies (GWASs). However, choosing the relevant annotations for interpreting …

Genetic variants associated with complex human diseases show wide variation across multiple populations

A Adeyemo, C Rotimi - Public health genomics, 2009 - karger.com
Background: The wide use of genome wide association studies (GWAS) has led to the
successful identification of multiple genetic susceptibility variants to several complex human …

Genetics of 35 blood and urine biomarkers in the UK Biobank

N Sinnott-Armstrong, Y Tanigawa, D Amar, N Mars… - Nature …, 2021 - nature.com
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …

Multi-ethnic studies in complex traits

J Fu, EAM Festen, C Wijmenga - Human molecular genetics, 2011 - academic.oup.com
The successes of genome-wide association (GWA) studies have mainly come from studies
performed in populations of European descent. Since complex traits are characterized by …

[PDF][PDF] Sequence variants in three loci influence monocyte counts and erythrocyte volume

MAR Ferreira, JJ Hottenga, NM Warrington… - The American Journal of …, 2009 - cell.com
Blood cells participate in vital physiological processes, and their numbers are tightly
regulated so that homeostasis is maintained. Disruption of key regulatory mechanisms …