[HTML][HTML] The emergence of powerful oral anti-COVID-19 drugs in the post-vaccine era

H Fan, F Lou, J Fan, M Li, Y Tong - The Lancet Microbe, 2022 - thelancet.com
The quest for effective drugs to treat COVID-19 has been a priority since the outbreak of the
disease. The clinical application of remdesivir has been greatly restricted by the need for …

Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled …

SH Khoo, R FitzGerald, G Saunders… - The Lancet Infectious …, 2023 - thelancet.com
Background The antiviral drug molnupiravir was licensed for treating at-risk patients with
COVID-19 on the basis of data from unvaccinated adults. We aimed to evaluate the safety …

RETRACTED ARTICLE: Safety and efficacy of favipiravir versus hydroxychloroquine in management of COVID-19: A randomised controlled trial

HM Dabbous, MH El-Sayed, G El Assal, H Elghazaly… - Scientific reports, 2021 - nature.com
Favipiravir is considered a potential treatment for COVID-19 due its efficacy against different
viral infections. We aimed to explore the safety and efficacy of favipiravir in treatment of …

Real-world clinical outcomes of molnupiravir for the treatment of mild to moderate COVID-19 in adult patients during the dominance of the Omicron variant: a meta …

C Huang, TL Lu, L Lin - Antibiotics, 2023 - mdpi.com
Introduction: The therapeutic impact of molnupiravir in the Omicron variant phase is
unknown. The goal of the current meta-analysis was to compare the real-world clinical …

Safety and Effectiveness of Molnupiravir (LAGEVRIO®) Capsules in Japanese Patients with COVID-19: Interim Report of Post-marketing Surveillance in Japan

M Kimata, A Watanabe, Y Yanagida… - Infectious diseases and …, 2023 - Springer
Introduction Molnupiravir is an oral antiviral drug that received special approval for
emergency use in Japan on December 24 2021 for infectious disease caused by severe …

Discovery, development, and patent trends on molnupiravir: a prospective oral treatment for COVID-19

M Imran, M Kumar Arora, SMB Asdaq, SA Khan… - Molecules, 2021 - mdpi.com
The COVID-19 pandemic needs no introduction at present. Only a few treatments are
available for this disease, including remdesivir and favipiravir. Accordingly, the …

New perspectives on antimicrobial agents: molnupiravir and nirmatrelvir/ritonavir for treatment of COVID-19

RL Atmar, N Finch - Antimicrobial agents and chemotherapy, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged to cause
pandemic respiratory disease in the past 2 years, leading to significant worldwide morbidity …

Outpatient treatment of confirmed COVID-19: a living, rapid evidence review for the American College of Physicians (Version 2)

I Sommer, D Ledinger, K Thaler… - Annals of internal …, 2023 - acpjournals.org
Background: Clinicians and patients want to know the benefits and harms of outpatient
treatment options for the Omicron variant of SARS-CoV-2. Purpose: To assess the benefits …

Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance

R Flisiak, D Zarębska-Michaluk, M Rogalska… - Pharmacological …, 2022 - Springer
Background The real-world effectiveness of molnupiravir (MOL) during the dominance of
Omicron SARS-CoV-2 lineage is urgently needed since the available data relate to the …

Pharmacokinetics of lopinavir and ritonavir in patients hospitalized with coronavirus disease 2019 (COVID-19)

C Schoergenhofer, B Jilma, T Stimpfl… - Annals of internal …, 2020 - acpjournals.org
Background: The coronavirus disease 2019 (COVID-19) pandemic has rapidly spread
around the world, and the lack of effective treatment has fueled a global search for the …