[HTML][HTML] The clinical efficacy and safety of anti-viral agents for non-hospitalized patients with COVID-19: a systematic review and network meta-analysis of randomized …

CC Lai, YH Wang, KH Chen, CH Chen, CY Wang - Viruses, 2022 - mdpi.com
This network meta-analysis compared the clinical efficacy and safety of anti-viral agents for
the prevention of disease progression among non-hospitalized patients with COVID-19 …

[HTML][HTML] Efficacy and safety of favipiravir in treating COVID-19 patients: a meta-analysis of randomized control trials

S Batool, K Vuthaluru, A Hassan, O Bseiso, Z Tehseen… - Cureus, 2023 - ncbi.nlm.nih.gov
This meta-analysis was conducted with the aim to assess the safety and efficacy of
favipiravir in treating patients with coronavirus disease 2019 (COVID-19). It was carried out …

Molnupiravir and nirmatrelvir-ritonavir: oral coronavirus disease 2019 antiviral drugs

LD Saravolatz, S Depcinski… - Clinical Infectious …, 2023 - academic.oup.com
At a crucial time with rapid spread of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) Omicron variant globally, the United States Food and Drug Administration …

Human safety, tolerability, and pharmacokinetics of molnupiravir, a novel broad-spectrum oral antiviral agent with activity against SARS-CoV-2

WP Painter, W Holman, JA Bush… - Antimicrobial agents …, 2021 - Am Soc Microbiol
ABSTRACT Molnupiravir (EIDD-2801/MK-4482), the prodrug of the active antiviral
ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931), has activity against a …

Real-world effectiveness of molnupiravir and nirmatrelvir/ritonavir as treatments for COVID-19 in patients at high risk

D Paraskevis, M Gkova, K Mellou… - The Journal of …, 2023 - academic.oup.com
Background Using a retrospective cohort study design, we aimed to evaluate the
effectiveness of molnupiravir and nirmatrelvir/ritonavir in patients with SARS-CoV-2 who …

A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus

WA Fischer, JJ Eron Jr, W Holman, MS Cohen… - Science translational …, 2021 - science.org
There is an urgent need for an effective, oral, direct-acting therapeutic to block transmission
of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent progression …

Covid-19: UK becomes first country to authorise antiviral molnupiravir

E Mahase - 2021 - bmj.com
Interim phase III trial results, released through a press release by the drug's manufacturer,
MSD, found that molnupiravir reduced the risk of admission to hospital or death by around …

Oral antiviral medications for COVID-19

LA Petty, PN Malani - JAMA, 2022 - jamanetwork.com
Twonewantiviralmedications, ritonavir-boostednirmatrelvir (Paxlovid, ie, nirmatrelvir-
ritonavir) and molnupiravir (Lagevrio), are currently availableintheUSunderemergencyuseautho …

Molnupiravir: Mechanism of action, clinical, and translational science

BM Maas, J Strizki, RR Miller, S Kumar… - Clinical and …, 2024 - Wiley Online Library
Molnupiravir is an oral prodrug of the broadly active, antiviral ribonucleoside analog N‐
hydroxycytidine (NHC). The primary circulating metabolite NHC is taken up into cells and …

[HTML][HTML] Molnupiravir: first approval

YY Syed - Drugs, 2022 - Springer
Molnupiravir (Lagevrio®) is an orally-administered antiviral prodrug that inhibits replication
of RNA viruses through viral error induction. It is being developed by Merck and Ridgeback …