Interferon (IFN)-λ forms the type III IFN family. Although they signal through distinct receptors,
type I (IFN-α/β) and type III IFNs elicit remarkably similar responses in cells. However, in …

Type-III interferons (IFN-λ, IFNL) are the most recently described family of IFNs. This family of
innate cytokines are increasingly being ascribed pivotal roles in host–pathogen interactions …

Virus-infected cells secrete a broad range of interferons (IFN) which confer resistance to yet
uninfected cells by triggering the synthesis of antiviral factors. The relative contributions of …

Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …

Interferons (IFNs) are generally considered antiviral cytokines, yet the newly discovered IFN-
λ4 is linked with the failure to clear hepatitis C virus (HCV) infection either spontaneously or …

Type III IFNs are important mediators of antiviral immunity. IFN-λ4 is a unique type III IFN
because it is produced only in individuals who carry a dG allele of a genetic variant …

Interferons (IFN) exert antiviral, immunomodulatory and cytostatic activities. IFN-α/β (type I
IFN) and IFN-λ (type III IFN) bind distinct receptors, but regulate similar sets of genes and …

Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to
play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique …

Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as
the first line of defense against virus infection and regulate the development of both innate …

Interferons (IFNs) can serve as the first line of immune defense against viral infection. The
identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral …