We performed genetic association studies in a population-based breast cancer case–control
study analysing polymorphisms in genes involved in homologous recombination (NBS1 …

DNA double strand break (DSB) repair dysfunction increases the risk of familial and
sporadic breast cancer. Advances in the understanding of genetic predisposition to breast …

The double-strand break DNA repair pathway has been implicated in breast carcinogenesis.
We evaluated the association between 19 polymorphisms in seven genes in this pathway …

Genetic polymorphisms in double-strand break repair genes may influence DNA repair
capacity and, in turn, confer predisposition to breast cancer. We prospectively assessed the …

The possible role for DNA repair deficiencies in cancer development, namely in breast
cancer has been the subject of increasing interest since it has been reported that breast …

The purpose of this study was to evaluate the role of polymorphisms in DNA repair genes as
genetic indicators of susceptibility to familial and sporadic breast cancer. We analysed DNA …

Mammalian cells are constantly exposed to genotoxic agents from both endogenous and
exogenous sources. Genetic variability in DNA repair contributes to deficient repair and …

This study investigates the role of two nonsynonymous single nucleotide polymorphisms in
DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1)-R399Q and X-ray …

XRCC1 (X-ray repair cross-complementing group 1) is a base excision repair protein that
plays a central role in the repair of DNA base damage and strand breaks. A common …

Deficiencies in DNA repair have been hypothesized to increase cancer risk and excess
cancer incidence is a feature of inherited diseases caused by defects in DNA damage …