Genome‐wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression
Opioid use disorder (OUD) and mental disorders are often comorbid, with increased
morbidity and mortality. The causes underlying this relationship are poorly understood …
morbidity and mortality. The causes underlying this relationship are poorly understood …
Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence
N Fernàndez‐Castillo, C Roncero… - Genes, Brain and …, 2013 - Wiley Online Library
Cocaine dependence is a neuropsychiatric disorder in which both environmental and
genetic factors are involved. Several processes, that include reward and neuroadaptations …
genetic factors are involved. Several processes, that include reward and neuroadaptations …
Cocaine self-administration alters transcriptome-wide responses in the brain's reward circuitry
Background Global changes in gene expression underlying circuit and behavioral
dysregulation associated with cocaine addiction remain incompletely understood. Here, we …
dysregulation associated with cocaine addiction remain incompletely understood. Here, we …
Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions
During adolescence, frequent and heavy cannabis use can lead to serious adverse health
effects and cannabis use disorder (CUD). Rodent models of adolescent exposure to the …
effects and cannabis use disorder (CUD). Rodent models of adolescent exposure to the …
Neuroepigenetics and addiction
DM Walker, EJ Nestler - Handbook of clinical neurology, 2018 - Elsevier
Drug addiction involves long-term behavioral abnormalities that arise in response to
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …
Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens
J Feng, M Wilkinson, X Liu, I Purushothaman… - Genome biology, 2014 - Springer
Background Increasing evidence supports a role for altered gene expression in mediating
the lasting effects of cocaine on the brain, and recent work has demonstrated the …
the lasting effects of cocaine on the brain, and recent work has demonstrated the …
Addiction-associated genetic variants implicate brain cell type-and region-specific cis-regulatory elements in addiction neurobiology
Recent large genome-wide association studies have identified multiple confident risk loci
linked to addiction-associated behavioral traits. Most genetic variants linked to addiction …
linked to addiction-associated behavioral traits. Most genetic variants linked to addiction …
Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in a panel of inbred and recombinant inbred mice
To identify addiction genes, we evaluate intravenous self-administration of cocaine or saline
in 84 inbred and recombinant inbred mouse strains over 10 days. We integrate the behavior …
in 84 inbred and recombinant inbred mouse strains over 10 days. We integrate the behavior …
Substance use disorders: a theory‐driven approach to the integration of genetics and neuroimaging
HC Karoly, N Harlaar… - Annals of the New York …, 2013 - Wiley Online Library
The etiology of substance use disorders is related to changes in neuronal systems involved
in reward anticipation, negative affect, and withdrawal, as well as to alterations in inhibition …
in reward anticipation, negative affect, and withdrawal, as well as to alterations in inhibition …
Common single nucleotide variants underlying drug addiction: more than a decade of research
Drug‐related phenotypes are common complex and highly heritable traits. In the last few
years, candidate gene (CGAS) and genome‐wide association studies (GWAS) have …
years, candidate gene (CGAS) and genome‐wide association studies (GWAS) have …