Cardiac disorders remain one of the most important causes of death in the world. Oxidative
stress has been suggested as one of the molecular mechanisms involved in drug-induced …

Silymarin 'milk thistle'(Silybum marianum) plant, has been used for years for treatment of
different diseases such as liver and gallbladder disorders, protecting liver against snake bite …

Silymarin is a complex of five major compounds, and silibinin is the most biologically active
component of the complex. The aim of this study was to investigate, evaluate and confirm the …

Ischemia-reperfusion injuries (IRI) occur in different clinical conditions such as stroke,
trauma, organ transplantation, and so on. Ischemia damages mainly arise from oxygen …

Silymarin, derived from Silybum marianum, has been used in traditional medicine for various
ailments. In this study, the cardioprotective and hepatoprotective effects of silymarin against …

Cardiovascular diseases (CVDs) are considered as the major reason for mortality and
morbidity worldwide. Substantial evidence suggests that increased oxidative stress plays a …

Widespread use of herbal drugs because of their protective effects on different organs
toxicity has been shown in many studies. These protective effects have been illustrated in …

Silymarin, an extract of flavonolignans from the dried fruits of milk thistle (Silybum marianum
L. Gaertneri) and its constituents silibinin, dehydrosilibinin, silychristin and silydianin were …

Doxorubicin (DOX) is the most effective and frequently used anticancer drug. This work
aimed to study the protective role of silymarin (SIL) against DOX induced cardiotoxicity. Forty …

BACKGROUND There is comprehensive experimental and clinical evidence that either
exogenous supplementation of natural antioxidants or augmentation of endogenous …