UV‐induced formation of pyrimidine dimers in DNA is a major deleterious event in both
eukaryotic and prokaryotic cells. Accumulation of cyclobutane pyrimidine dimers and …

Cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (6-
4PPs) are the two main classes of mutagenic DNA damages induced by UVB radiation …

The formation of DNA photoproducts by ultraviolet (UV) light is responsible for induction of
mutations and development of skin cancer. To understand UV mutagenesis, it is important to …

In this paper we present a sensitive procedure to determine specifically the induction as well
as the removal of cyclobutane pyrimidine dimers in intact mammalian cells without …

The mutational specificity of UV-light is characterized by an abundance of C to T transition
mutations at dipyrimidines containing cytosine or 5-methylcytosine. A significant percentage …

Classically, the nucleotide excision repair (NER) of cyclobutane pyrimidine dimers (CPD) is
a lengthy process (t 1/2> 48 h). Using the T4 endonuclease V-modified comet assay, we …

Absorption of solar ultraviolet (UV) radiation by DNA leads to the formation of the highly
mutagenic cyclobutane pyrimidine dimer (CPD). The mutagenicity of CPD is caused, in part …

Direct repair of UV‐induced DNA lesions represents an elegant method for many organisms
to deal with these highly mutagenic and cytotoxic compounds. Although the participating …

The most prevalent forms of cancer in humans are the non-melanoma skin cancers, with
over a million new cases diagnosed in the United States annually. The portions of the body …

Abstract Cyclobutane pyrimidine dimers and (6–4) photoproducts are the two major classes
of lesions produced in DNA by UVB and UVC irradiation. Their distribution along genes is …