Systems Approaches in the Common Metabolomics in Acute Lymphoblastic Leukemia and Rhabdomyosarcoma Cells: A Computational Approach

A Zaravinos, AN Tsartsalis, A Tagka, A Kotoulas… - GeNeDis 2020 …, 2021 - Springer
Acute lymphoblastic leukemia is the most common childhood malignancy.
Rhabdomyosarcoma, on the other hand, is a rare type of malignancy which belongs to the …

Metabolic Profiling as an Approach to Differentiate T-Cell Acute Lymphoblastic Leukemia Cell Lines Belonging to the Same Genetic Subgroup

HBR Alabed, RM Pellegrino, S Buratta… - International Journal of …, 2024 - mdpi.com
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive tumor mainly affecting children
and adolescents. It is driven by multiple genetic mutations that together define the leukemic …

Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: a systems biology approach

GI Lambrou, A Zaravinos… - International …, 2012 - spandidos-publications.com
A part of current research has intensively been focused on the proliferation and metabolic
processes governing biological systems. Since the advent of high throughput methodologies …

[HTML][HTML] Systems biology of cancer: moving toward the integrative study of the metabolic alterations in cancer cells

CE Hernández Patiño, G Jaime-Muñoz… - Frontiers in …, 2013 - frontiersin.org
One of the main objectives in systems biology is to understand the biological mechanisms
that give rise to the phenotype of a microorganism by using high-throughput technologies …

[HTML][HTML] Altered metabolism in cancer

JW Locasale, LC Cantley - BMC biology, 2010 - Springer
Cancer cells have different metabolic requirements from their normal counterparts.
Understanding the consequences of this differential metabolism requires a detailed …

[HTML][HTML] Modeling core metabolism in cancer cells: surveying the topology underlying the Warburg effect

O Resendis-Antonio, A Checa, S Encarnación - PloS one, 2010 - journals.plos.org
Background Alterations on glucose consumption and biosynthetic activity of amino acids,
lipids and nucleotides are metabolic changes for sustaining cell proliferation in cancer cells …

[HTML][HTML] Further steps toward functional systems biology of cancer

E Hernández-Lemus - Frontiers in Physiology, 2013 - frontiersin.org
Systems biology analyses in cancer are rapidly changing from merely descriptive efforts in
the high-throughput experimental works and overtly technical, calculation-centered studies …

Metabolic network modeling approaches for investigating the “hungry cancer”

AK Sharma, R König - Seminars in cancer biology, 2013 - Elsevier
Metabolism is the functional phenotype of a cell, at a given condition, resulting from an
intricate interplay of various regulatory processes. The study of these dynamic metabolic …

Metabolic cancer biology: structural-based analysis of cancer as a metabolic disease, new sights and opportunities for disease treatment

A Masoudi-Nejad, Y Asgari - Seminars in cancer biology, 2015 - Elsevier
The cancer cell metabolism or the Warburg effect discovery goes back to 1924 when, for the
first time Otto Warburg observed, in contrast to the normal cells, cancer cells have different …

[Retracted] The Study on the Pathogenesis of Pediatric Lymphoma Based on the Combination of Pseudotargeted and Targeted Metabolomics

H Sun, N Chen, X Wang, N Li, S Wang… - BioMed Research …, 2021 - Wiley Online Library
Pediatric lymphoma is a kind of malignant tumor with high mortality. The complexity of
pediatric lymphoma shows a great challenge for effective diagnosis and treatment. In order …