Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus

L Josset, VD Menachery, LE Gralinski, S Agnihothram… - MBio, 2013 - Am Soc Microbiol
ABSTRACT A novel human coronavirus (HCoV-EMC) was recently identified in the Middle
East as the causative agent of a severe acute respiratory syndrome (SARS) resembling the …

Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

MA Müller, VS Raj, D Muth, B Meyer, S Kallies… - MBio, 2012 - Am Soc Microbiol
ABSTRACT A new human coronavirus (hCoV-EMC) has emerged very recently in the
Middle East. The clinical presentation resembled that of the severe acute respiratory …

Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome …

F Zielecki, M Weber, M Eickmann… - Journal of …, 2013 - Am Soc Microbiol
Infections with human coronavirus EMC (HCoV-EMC) are associated with severe
pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome …

[HTML][HTML] Identification of two critical amino acid residues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism …

XX Qu, P Hao, XJ Song, SM Jiang, YX Liu… - Journal of Biological …, 2005 - ASBMB
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a recently identified human
coronavirus. The extremely high homology of the viral genomic sequences between the …

Replication of severe acute respiratory syndrome coronavirus 2 in human respiratory epithelium

A Milewska, A Kula-Pacurar, J Wadas, A Suder… - Journal of …, 2020 - Am Soc Microbiol
Currently, there are four seasonal coronaviruses associated with relatively mild respiratory
tract disease in humans. However, there is also a plethora of animal coronaviruses which …

Human coronavirus: host-pathogen interaction

TS Fung, DX Liu - Annual review of microbiology, 2019 - annualreviews.org
Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …

[HTML][HTML] A decade after SARS: strategies for controlling emerging coronaviruses

RL Graham, EF Donaldson, RS Baric - Nature Reviews Microbiology, 2013 - nature.com
Two novel coronaviruses have emerged in humans in the twenty-first century: severe acute
respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome …

Receptor recognition and cross-species infections of SARS coronavirus

F Li - Antiviral research, 2013 - Elsevier
Receptor recognition is a major determinant of the host range, cross-species infections, and
pathogenesis of the severe acute respiratory syndrome coronavirus (SARS-CoV). A defined …

[HTML][HTML] Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

R Channappanavar, S Perlman - Seminars in immunopathology, 2017 - Springer
Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic
coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and cause mild …

[HTML][HTML] Coronaviruses—drug discovery and therapeutic options

A Zumla, JFW Chan, EI Azhar, DSC Hui… - Nature reviews Drug …, 2016 - nature.com
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43,
HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract …