The potential use of stem cells for cochlear repair

MA Parker, DA Cotanche - Audiology and Neurotology, 2004 - karger.com
In light of the currently defined characteristics of stem cells, a re-evaluation of hair cell
regeneration in birds suggests that there may be a stem cell population located in the inner …

The potential role of endogenous stem cells in regeneration of the inner ear

R Martinez-Monedero, K Oshima, S Heller, ASB Edge - Hearing research, 2007 - Elsevier
Stem cells in various mammalian organs retain the capacity to renew themselves and may
be able to restore damaged tissue. Their existence has been proven by genetic tracer …

[PDF][PDF] Stem cells for the replacement of inner ear neurons and hair cells

R Martinez-Monedero, ASB Edge - International Journal of …, 2007 - researchgate.net
Stem cells in the nervous system have some capacity to restore damaged tissue.
Proliferation of stem cells endows them with self-renewal ability and accounts for in vitro …

Regeneration of inner ear cells from stem cell precursors—a future concept of hearing rehabilitation?

S Dazert, C Aletsee, D Brors, H Sudhoff… - DNA and cell …, 2003 - liebertpub.com
The use of stem cells offers new and powerful strategies for future tissue development and
engineering. Common features of stem cells are both their capacity for self-renewal and the …

Stem cells: a new hope for hearing loss therapy

Y Qiu, J Qiu - Hearing Loss: Mechanisms, Prevention and Cure, 2019 - Springer
Permanent hearing loss was considered which cannot be cured since cochlear hair cells
and primary afferent neurons cannot be regenerated. In recent years, due to the in-depth …

Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion …

MA Parker, DA Corliss, B Gray, JK Anderson… - Hearing research, 2007 - Elsevier
Most cases of hearing loss are caused by the death or dysfunction of one of the many
cochlear cell types. We examined whether cells from a neural stem cell line could replace …

Progenitor cells from the adult human inner ear

P Senn, A Mina, S Volkenstein… - The Anatomical …, 2020 - Wiley Online Library
Loss of inner ear hair cells leads to incurable balance and hearing disorders because these
sensory cells do not effectively regenerate in humans. A potential starting point for therapy …

Regenerative medicine in hearing recovery

E Simoni, G Orsini, M Chicca, S Bettini, V Franceschini… - Cytotherapy, 2017 - Elsevier
Hearing loss, or deafness, affects 360 million people worldwide of which about 32 million
are children. Deafness is irreversible when it involves sensory hair cell death because the …

Gene therapy and stem cell transplantation: strategies for hearing restoration

BW Kesser, AK Lalwani - Gene Therapy of Cochlear Deafness, 2009 - karger.com
Strategies to restore sensorineural hearing loss focus on the replacement of lost hair cells,
the specialized mechanoreceptors in the organ of Corti that convert the mechanical energy …

[HTML][HTML] Stem cell-based approaches: Possible route to hearing restoration?

MB Durán-Alonso - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Disabling hearing loss is the most common sensorineural disability worldwide. It affects
around 466 million people and its incidence is expected to rise to around 900 million people …