Integrating gene and protein expression reveals perturbed functional networks in Alzheimer's disease
Asymptomatic and symptomatic Alzheimer's disease (AD) subjects may present with
equivalent neuropathological burdens but have significantly different antemortem cognitive …
equivalent neuropathological burdens but have significantly different antemortem cognitive …
[HTML][HTML] A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer's disease
Here, we report proteomic analyses of 129 human cortical tissues to define changes
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …
[HTML][HTML] Hippocampal transcriptome profiling combined with protein-protein interaction analysis elucidates Alzheimer's disease pathways and genes
JGJ Van Rooij, LHH Meeter, S Melhem, DAT Nijholt… - Neurobiology of …, 2019 - Elsevier
Abstract Knowledge about the molecular mechanisms driving Alzheimer's disease (AD) is
still limited. To learn more about AD biology, we performed whole transcriptome sequencing …
still limited. To learn more about AD biology, we performed whole transcriptome sequencing …
Cell type-specific potential pathogenic genes and functional pathways in Alzheimer's Disease
XL Wang, L Li - BMC neurology, 2021 - Springer
Background Alzheimer's disease (AD) is a pervasive age-related and highly heritable
neurodegenerative disorder but has no effective therapy. The complex cellular …
neurodegenerative disorder but has no effective therapy. The complex cellular …
Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder affecting millions of
elderly individuals worldwide. Advances in the genetics of AD have led to new levels of …
elderly individuals worldwide. Advances in the genetics of AD have led to new levels of …
[HTML][HTML] Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer's disease
E Galea, LD Weinstock, R Larramona-Arcas… - Neurobiology of …, 2022 - Elsevier
The phenotypic transformation of astrocytes in Alzheimer's disease (AD) is still not well
understood. Recent analyses based on single-nucleus RNA sequencing of postmortem …
understood. Recent analyses based on single-nucleus RNA sequencing of postmortem …
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease
Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
by progressive cognitive impairment and neurodegeneration. However, despite extensive …