Schizophrenia is a highly polygenic brain disorder. The main hypothesis for disease etiology
in schizophrenia primarily focuses on the role of dysfunctional synaptic transmission …

Given that the genetic risk for schizophrenia is highly polygenic and the effect sizes, even for
rare or de novo events, are modest at best, it has been suggested that multiple biological …

Schizophrenia, a debilitating disease with 1% prevalence in the general population, is
characterized by major neuropsychiatric symptoms, including delusions, hallucinations, and …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

Background The quest to understand the neurobiology of schizophrenia and bipolar
disorder is ongoing with multiple lines of evidence indicating abnormalities of glia …

Schizophrenia appears to bea neurodevelopmental disorder involving dysfunction prefrontal
and temporal cortical neural systems. Recent data implicate presynaptic changes in …

Large-scale genome-wide association studies (GWAS) have implicated many low-
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …

Schizophrenia is a complex highly heritable disorder. Genome-wide association studies
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …

Clinical, epidemiological, neuroimaging and postmortem data all suggest schizophrenia is a
neurodevelopmental disorder, and that synaptic disturbances might play a critical role in …

Abstract Changes in immune function are associated with variance in cognitive functioning
in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we …