Genetic factors account for up to 80% of the liability for schizophrenia and bipolar disorder.
Genome-wide association studies (GWAS) have successfully identified several single …

Background One third of people diagnosed with schizophrenia fail to respond adequately to
antipsychotic medication, resulting in persisting disabling symptoms, higher rates of …

Background Schizophrenia is a complex polygenic disorder with subtle, distributed
abnormalities in brain morphology. There are indications of shared genetic architecture …

A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci,
typically weighted by effect sizes estimated from a genome-wide association study. The …

Schizophrenia is a chronic debilitating psychiatric disorder with significant morbidity and
mortality. In this study, we used information from 337,484 UK Biobank participants and …

Genome-wide association studies (GWASs) have detected many susceptible variants for
common diseases, including psychiatric disorders. However, because of the small effect size …

Objective Schizophrenia (SZ) and bipolar disorder (BD) are heritable, polygenic disorders
with shared clinical characteristics and genetic risk indicating a psychosis continuum. This is …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Genetics provides two major opportunities for understanding human disease—as a
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …

Matt was in many ways the stereotypical “all-American” teenager: a multisport athlete, class
president, and valedictorian of his high school. It seemed preordained that he would attend …