All proteins in mammalian cells are continually being degraded and replaced. In the cytosol,
nucleus, and organelles, individual proteins are degraded at widely differing rates; some …

All intracellular proteins and many extracellular proteins are continually “turning over”; ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

Studies of many different rodent models of muscle wasting have indicated that accelerated
proteolysis via the ubiquitin-proteasome pathway is the principal cause of muscle atrophy …

Publisher Summary This chapter discusses the methods available to study skeletal muscle
protein breakdown, and the role of three major proteolytic pathways so far well characterized …

Ca” cer cachexia Cache& is a poorly understood syndrome charwtw ized by anorexia,
weight loss, profound metabolic abnormalities and wive host wastina that mav result in …

Skeletal muscle adapts its mass as consequence of physical activity, metabolism and
hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the …

Recent studies have suggested that activation of the ubiquitin-proteasome pathway is
primarily responsible for the rapid loss of muscle proteins in various types of atrophy. The …

Muscle atrophy complicates many diseases as well as aging, and its presence predicts both
decreased quality of life and survival. Much work has been conducted to define the …

The rapid loss of muscle mass that accompanies many disease states, such as cancer or
sepsis, is primarily a result of increased protein breakdown in muscle, and several …

Muscle cachexia induced by sepsis, severe injury, cancer, and a number of other catabolic
conditions is mainly caused by increased protein degradation, in particular breakdown of …