Approximately 5% of patients with Wilms tumor present with synchronous bilateral disease.
The development of synchronous bilateral Wilms tumor (BWT) is highly suggestive of a …

Developing synchronous bilateral Wilms tumor suggests an underlying (epi) genetic
predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or …

Wilms' tumor is the most common renal malignancy in children. In addition to staging,
molecular risk stratification, such as loss of heterozygosity (LOH) in Chromosomes 1 and 16 …

Abstract Wilms' tumor (WT), the most common childhood kidney cancer, develops in
association with an underlying germline predisposition in up to 15% of cases. Germline …

Even before Knudson's two hit hypothesis was proven at a molecular level for
retinoblastoma, there was emerging evidence that the genetics of Wilms tumor involved …

Survival in patients with Wilms tumor (WT) is excellent compared with other pediatric
malignancies and adult renal tumors. Treatment-related long-term morbidity and mortality in …

Disease characteristics. Wilms tumor (nephroblastoma) is an embryonal malignancy of the
kidney. Current models of Wilms tumor development propose that a genetic mutation …

Background A primary objective of Children's Oncology Group study AREN0534 (Treatment
for Patients With Multicentric or Bilaterally Predisposed, Unilateral Wilms Tumor) was to …

This study explores the genomic alterations that contribute to the formation of a unique
subset of low-risk, epithelial differentiated, favorable histology Wilms tumors (WT), tumors …

Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are
implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we …