Substantial COVID-19 research investment has been allocated to randomized clinical trials
(RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or …

Objectives The emergence of SARS‐CoV‐2 has presented clinicians with a difficult
therapeutic dilemma. With supportive care as the current mainstay of treatment, the fatality …

Purpose To assess efficacy and safety of chloroquine (CQ)/hydroxychloroquine (HCQ) for
treatment or prophylaxis of COVID-19 in adult humans. Materials and methods MEDLINE …

Background Hydroxychloroquine and chloroquine have been proposed as treatments for
coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from …

Objectives Clinical studies of chloroquine (CQ) and hydroxychloroquine (HCQ) in COVID-19
disease reported conflicting results. We sought to systematically evaluate the effect of CQ …

Background Hydroxychloroquine or chloroquine with or without azithromycin have been
widely promoted to treat coronavirus disease 2019 (COVID-19) following early in vitro …

Summary Background Previous Randomised controlled trials (RCT) evaluating chloroquine
and hydroxychloroquine in non-hospitalised COVID-19 patients have found no significant …

Many recent studies have investigated the role of either Chloroquine (CQ) or
Hydroxychloroquine (HCQ) alone or in combination with azithromycin (AZM) in the …

PETAL Clinical Trials Network, focused on hospitalized patients with moderate to severe
disease. In this wellconducted, appropriately powered clinical trial, the authors randomized …

Importance Data on the efficacy of hydroxychloroquine for the treatment of coronavirus
disease 2019 (COVID-19) are needed. Objective To determine whether hydroxychloroquine …