Development of drug resistance has considerably limited the efficacy of cancer treatments,
including chemotherapy and targeted therapies. Hence, understanding the molecular …

Drug resistance is a major obstacle to successful cancer treatment. The identification of new
approaches that can circumvent this problem will lead to improved clinical strategies and …

Chemotherapy has been widely used in treatment of cancer, both as systemic therapy and
as part of local treatment. Unfortunately, many kinds of cancer are still refractory to …

MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

Drug resistance is a major problem in the treatment of cancer patients. Resistance can
develop after prolonged cycles of chemotherapy or can be present intrinsically in the patient …

The discovery of oncogene addiction dramatically changed the therapeutic approach for
cancer treatment, and many drugs targeting specific molecular alterations are now in clinics …

Chemoresistance is one of the main problems in the therapy of cancer. There are a number
of different molecular mechanisms through which a cancer cell acquires resistance to a …

The discovery of small regulatory noncoding RNAs revolutionized our thinking on gene
regulation. The class of microRNAs (miRs), a group of small noncoding RNAs (20–22 nt in …

The most common cause of cancer relapse is drug resistance, acquired or intrinsic, which
strongly limits the efficacy of both conventional and new targeted chemotherapy. MicroRNAs …

MicroRNAs are small RNA transcripts involved in fine-tuning of several cellular mechanisms
and pathways crucial for maintaining cells' homeostasis like apoptosis, differentiation …