The process of cell fate determination has been depicted intuitively as cells travelling and
resting on a rugged landscape, which has been probed by various theoretical studies …

Background The image of the" epigenetic landscape", with a series of branching valleys and
ridges depicting stable cellular states and the barriers between those states, has been a …

Cellular differentiation, reprogramming and transdifferentiation are determined by
underlying gene regulatory networks. Non-adiabatic regulation via slow binding/unbinding …

Organisms utilize gene regulatory networks (GRN) to make fate decisions, but the regulatory
mechanisms of transcription factors (TF) in GRNs are exceedingly intricate. A longstanding …

Understanding cell fate selection remains a central challenge in developmental biology. We
present a class of simple yet biologically motivated mathematical models for cell …

The well-known Waddington's epigenetic landscape of cell-fate determination is not static
but varies because of the dynamic gene regulation during development. However, existing …

Multipotent stem or progenitor cells undergo a sequential series of binary fate decisions,
which ultimately generate the diversity of differentiated cells. Efforts to understand cell fate …

Recent progress in stem cell biology, notably cell fate conversion, calls for novel theoretical
understanding for cell differentiation. The existing qualitative concept of Waddington's …

The global regulation of cell growth rate on gene expression perturbs the performance of
gene networks, which would impose complex variations on the cell-fate decision landscape …

Engineering beyond landscapes The Waddington landscape has offered an intuitive
framework to conceptualize cell fate, grounded in our innate understanding of the physical …