Antisense oligonucleotides (ASOs) are promising tools for gene silencing and have been
exploited as therapeutics for human disease. However, delivery of therapeutic ASOs to …

Immunomodulatory therapy has become a promising method for the clinical treatment of
many diseases. Recently, pilot studies revealed that immunomodulatory therapy exhibited …

Atherosclerosis remains the leading cause of a broad spectrum of deadliest cardiovascular
diseases. MicroRNA‐33 is a new therapeutic target for atherosclerosis due to its diverse …

Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a
wide range of biomedical applications, but there are many challenges facing its therapeutic …

Shutting down glucose supply by glucose oxidase (GOx) to starve tumors has been
considered to be an attractive strategy in cancerous starvation therapy. Nevertheless, the in …

Atherosclerosis (AS) is a leading cause of vascular diseases that severely threats the human
health due to the lack of efficient therapeutic methods. During the development and progress …

A “closed-loop” insulin delivery system that can mimic the dynamic and glucose-responsive
insulin secretion as islet β-cells is desirable for the therapy of type 1 and advanced type 2 …

Macrophages play essential roles in the progression of rheumatoid arthritis (RA), which are
polarized into the pro‐inflammatory M1 phenotype with significant oxidative stress and …

Small interfering RNA (siRNA) has emerged as a powerful tool in gene therapy to suppress
gene expression. However, the fragile properties of siRNA and the low efficiency with non …

MicroRNA (miRNA) represents a promising class of therapeutic nucleic acid drugs, while
delivery challenges remain that impede the advancement of miRNA therapy, largely …