One of the major challenges in tissue engineering of bone substitutes remains
vascularization of the transplant. We have developed a three-dimensional collagen-based …

Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …

The neovascularization of three‐dimensional voluminous tissues, such as bone, represents
an important challenge in tissue engineering applications. The formation of a preformed …

Cell spheroids represent attractive building units for bone tissue engineering, because they
provide a threedimensional environment with intensive direct cellcell contacts. Moreover …

Bone is a highly vascularized tissue, in which vascularization and mineralization are
concurrent processes during skeletal development. Indeed, both components should be …

Vascularization of engineered bone tissue is critical for ensuring its survival after
implantation. In vitro pre-vascularization of bone grafts with endothelial cells is a promising …

One of the major problems with bone tissue engineering is the development of a rapid
vascularization after implantation to supply the growing osteoblast cells with the nutrients to …

Addressing the problem of vascularization is of vital importance when engineering three-
dimensional (3D) tissues. Endothelial cells are increasingly used in tissue-engineered …

To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

Angiogenesis is a key element in early wound healing and is considered important for tissue
regeneration and for directing inflammatory cells to the wound site. The improvement of …