Normal maintenance of human motivation depends on the integrity of subcortical structures
that link the prefrontal cortex with the limbic system. Structural and functional disruption of …

Apathy has been defined as lack of motivation. It has been traditionally considered as a
symptom of psychiatric disorders, such as major depression and schizophrenia, but more …

Psychiatric symptoms are important non-motor features in PD, which occur at high frequency
and have significant impact on health related quality of life. This review concentrates on the …

The objective of this study was to test the hypothesis that apathy and depression are
dissociable in Parkinson disease (PD) by conducting a confirmatory factor analysis (CFA) of …

In people with Parkinson's disease, neuropsychiatric signs and symptoms are common
throughout the disease course. These symptoms can be disabling and as clinically relevant …

Objective To empirically test whether apathy and impulse control disorders (ICDs) represent
independent, opposite ends of a motivational spectrum. Methods In this single-center, cross …

Abstract See Schrag and Politis (doi: 10.1093/aww190) for a scientific commentary on this
article. Apathy, which can occur separately or in combination with depression and anxiety, is …

The past few decades have seen growing interest in the neuropsychiatric syndrome of
apathy, conceptualised as a loss of motivation manifesting as a reduction of goal-directed …

Neuropsychiatric symptoms are common non-motor symptoms in Parkinson's disease (PD).
Apathy and impulse control disorders (ICD) are two opposite motivational expressions of a …

Depression, anxiety and apathy are common mood disturbances in Parkinson's disease
(PD) but their pathophysiology is unclear. Advanced neuroimaging has been increasingly …