Currently circulating SARS-CoV-2 variants acquired convergent mutations at receptor-
binding domain (RBD) hot spots. Their impact on viral infection, transmission, and efficacy of …

Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we
compare neutralization of Omicron BA. 1, BA. 1.1, and BA. 2. BA. 2 RBD has slightly higher …

Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …

The SARS-CoV-2 Omicron Variant of Concern (B. 1.1. 529) has spread rapidly in many
countries. With a spike that is highly diverged from that of the pandemic founder, it escapes …

Summary SARS-CoV-2 Omicron BA. 2.75 subvariant has evolved to a series of progeny
variants carrying several additional mutations in the receptor-binding domain (RBD). Here …

Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus
disease 2019 (COVID-19), has led to a pandemic with severe economic losses. The viral …

Most COVID-19 antibody therapies rely on binding the SARS-CoV-2 receptor binding
domain (RBD). However, heavily mutated variants such as Omicron and its sublineages …

SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD)
that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep …

The landscape of SARS-CoV-2 variants dramatically diversified with the simultaneous
appearance of multiple subvariants originating from BA. 2, BA. 4, and BA. 5 Omicron sub …

Summary In November 2021, Omicron BA. 1, containing a raft of new spike mutations,
emerged and quickly spread globally. Intense selection pressure to escape the antibody …