Despite decades of intense research, disease-modifying therapeutic approaches for
Alzheimer's disease (AD) are still very much needed. Apart from the extensively analyzed …

Aging is characterized by a significant decline of metabolic and hormonal functions, which
often facilitates the onset of severe age-associated pathologies. One outstanding example of …

The 'amyloid cascade hypothesis' proposes that disturbances in amyloid metabolism cause
Alzheimer's disease (AD). However, a comprehensive explanation of the mechanisms …

Cellular and molecular processes leading to abnormal accumulation of β amyloid in the
brain are slowly being uncovered. A potential involvement of insulin and insulin-like growth …

The quality control of protein homoeostasis deteriorates with aging, causing the
accumulation of misfolded proteins and neurodegeneration. Thus, in AD (Alzheimer's …

Alzheimer's disease (AD) is a growing problem worldwide, and there are currently no
effective treatments for this devastating disease. The neurotrophic growth factors insulin and …

Recent data suggest that brains of patients with Alzheimer's disease (AD) are insulin and
insulin-like growth factor-1 (IGF-1) resistant. So far, there have been two different …

In different clinical studies, an association of type 2 diabetes and Alzheimer's disease (AD)
has been described. However, the underlying mechanisms are still unclear. One …

Alzheimer's disease (AD) is the most common cause of dementia in North America. Growing
evidence supports the concept that AD is fundamentally a metabolic disease that results in …

Background: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated
with dementia and Alzheimer's disease (AD). Studies on the association between IGF-I …