[HTML][HTML] Plasmalogens inhibit neuroinflammation and promote cognitive function

MS Hossain, S Mawatari, T Fujino - Brain Research Bulletin, 2023 - Elsevier
Neuroinflammation (NF) is defined as the activation of brain glial cells that are found in
neurodegenerative diseases including Alzheimer's disease (AD). It has been known that an …

Reduction of ether-type glycerophospholipids, plasmalogens, by NF-κB signal leading to microglial activation

MS Hossain, Y Abe, F Ali, M Youssef… - Journal of …, 2017 - Soc Neuroscience
Neuroinflammation characterized by activation of glial cells is observed in various
neurodegenerative diseases including Alzheimer's disease (AD). Although the reduction of …

Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

M Ifuku, T Katafuchi, S Mawatari, M Noda… - Journal of …, 2012 - Springer
Background Neuroinflammation involves the activation of glial cells in neurodegenerative
diseases such as Alzheimer's disease (AD). Plasmalogens (Pls) are glycerophospholipids …

[HTML][HTML] Plasmalogens eliminate aging-associated synaptic defects and microglia-mediated neuroinflammation in mice

J Gu, L Chen, R Sun, JL Wang, J Wang… - Frontiers in Molecular …, 2022 - frontiersin.org
Neurodegeneration is a pathological condition in which nervous system or neuron losses its
structure, function, or both leading to progressive neural degeneration. Growing evidence …

PUFA-plasmalogens attenuate the LPS-induced nitric oxide production by inhibiting the NF-kB, p38 MAPK and JNK pathways in microglial cells

M Youssef, A Ibrahim, K Akashi, MS Hossain - Neuroscience, 2019 - Elsevier
The special lipids plasmalogens (Pls) were reported to be reduced in the neurodegenerative
brains such as Alzheimer's disease where a marked increase of glial activation is often …

Biological functions of plasmalogens

MS Hossain, S Mawatari, T Fujino - Peroxisome biology: Experimental …, 2020 - Springer
Plasmalogens (Pls) are one kind of phospholipids enriched in the brain and other organs.
These lipids were thought to be involved in the membrane bilayer formation and anti-oxidant …

Plasmalogen in the brain: Effects on cognitive functions and behaviors attributable to its properties

J Udagawa, K Hino - Brain research bulletin, 2022 - Elsevier
Ether phospholipid compositions are altered in the plasma or brain of patients with brain
disorders, such as Alzheimer and Parkinson's disease, including those with psychiatric …

Oral ingestion of plasmalogens can attenuate the LPS-induced memory loss and microglial activation

MS Hossain, A Tajima, S Kotoura, T Katafuchi - … and biophysical research …, 2018 - Elsevier
Plasmalogens (Pls) are the special phospholipids which were reported to be reduced in
brain and blood samples of Alzheimer's disease (AD) patients, suggested a possibility that …

Effects of plasmalogens on systemic lipopolysaccharide‐induced glial activation and β‐amyloid accumulation in adult mice

T Katafuchi, M Ifuku, S Mawatari… - Annals of the New …, 2012 - Wiley Online Library
Neuroinflammation essentially involves an activation of glial cells as the cause/effect of
neurodegenerative diseases such as Alzheimer's disease (AD). Plasmalogens (Pls) are …

Plasmalogens and chronic inflammatory diseases

JC Bozelli Jr, S Azher, RM Epand - Frontiers in physiology, 2021 - frontiersin.org
It is becoming widely acknowledged that lipids play key roles in cellular function, regulating
a variety of biological processes. Lately, a subclass of glycerophospholipids, namely …