Microglia plays an important role in the production of inflammation in the central nervous
system. Excessive nerve inflammation can cause neuronal damage and neurodegenerative …

Neuronal cells are susceptible to many stresses, which will cause the apoptosis and
neurodegenerative diseases. The precise molecular mechanism behind the neuronal …

Alzheimer's disease (AD) is the leading cause of dementia worldwide giving rise to
devastating forms of cognitive decline, which impacts patients' lives and that of their proxies …

This review proposes that lipopolysaccharide (LPS, found in the wall of all Gram-negative
bacteria) could play a role in causing sporadic Alzheimer's disease (AD). This is based in …

Inflammation in the brain is a prominent feature in Alzheimer's disease (AD). Recent studies
suggest that chronic inflammation can be a consequence of failure to resolve the …

Acute inflammation is generally self-limited. However, if acute inflammation fails to resolve,
chronic inflammation can persist. The innate and adaptive immune systems, as well as …

Astrocytes and oligodendrocytes are known to play critical roles in the central nervous
system development, homeostasis and response to injury. In addition to their well-defined …

Neuroinflammation is part of the complex immune response within the central nervous
system (CNS), whose details have been partially elucidated. The CNS immune response …

In contrast with senescence-accelerated mice R1, SAM P8 show abnormal aging
characteristics. Changes occurring during aging could be mainly caused by free radical …

Background Analyses of brain samples from Alzheimer's disease (AD) patients may be
expected to help us improve our understanding of the pathogenesis of AD. Bioactive lipids …