Extensive transduction and enhanced spread of a modified AAV2 capsid in the non-human primate CNS

J Naidoo, LM Stanek, K Ohno, S Trewman… - Molecular Therapy, 2018 - cell.com
The present study was designed to characterize transduction of non-human primate brain
and spinal cord with a modified adeno-associated virus serotype 2, incapable of binding to …

Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9

J Dashkoff, EP Lerner, N Truong, JA Klickstein… - … Therapy Methods & …, 2016 - cell.com
The capacity of certain adeno-associated virus (AAV) vectors to cross the blood–brain
barrier after intravenous delivery offers a unique opportunity for noninvasive brain delivery …

Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates

SJ Gray, V Matagne, L Bachaboina, S Yadav… - Molecular Therapy, 2011 - cell.com
Other labs have previously reported the ability of adeno-associated virus serotype 9 (AAV9)
to cross the blood-brain barrier (BBB). In this report, we carefully characterized variables that …

Efficient gene transfer to the central nervous system by single-stranded Anc80L65

E Hudry, E Andres-Mateos, EP Lerner, A Volak… - … Therapy Methods & …, 2018 - cell.com
Adeno-associated viral vectors (AAVs) have demonstrated potential in applications for
neurologic disorders, and the discovery that some AAVs can cross the blood-brain barrier …

Intracerebroventricular delivery of self-complementary adeno-associated virus serotype 9 to the adult rat brain

A Donsante, Z McEachin, J Riley, CH Leung, L Kanz… - Gene therapy, 2016 - nature.com
Gene therapy for the central nervous system is poised to become a powerful treatment for
numerous neurological disorders. Adeno-associated viral vectors based on serotype 9 …

Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs

T Federici, JS Taub, GR Baum, SJ Gray, JC Grieger… - Gene therapy, 2012 - nature.com
Adeno-associated viral vector 9 (AAV9) has recently been shown to penetrate the blood–
brain barrier via intravascular administration, making it a good candidate for diffuse gene …

Intracisternal delivery of AAV9 results in oligodendrocyte and motor neuron transduction in the whole central nervous system of cats

T Bucher, L Dubreil, MA Colle, M Maquigneau… - Gene therapy, 2014 - nature.com
Systemic and intracerebrospinal fluid delivery of adeno-associated virus serotype 9 (AAV9)
has been shown to achieve widespread gene delivery to the central nervous system (CNS) …

Systemic delivery of tyrosine‐mutant AAV vectors results in robust transduction of neurons in adult mice

A Iida, N Takino, H Miyauchi… - BioMed research …, 2013 - Wiley Online Library
Recombinant adeno‐associated virus (AAV) vectors are powerful tools for both basic
neuroscience experiments and clinical gene therapies for neurological diseases …

Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates

PA Lawlor, RJ Bland, A Mouravlev, D Young… - Molecular therapy, 2009 - cell.com
Adeno-associated viral (AAV) vectors have become the primary delivery agent for somatic
gene transfer into the central nervous system (CNS). To date, AAV-mediated gene delivery …

Mouse gender influences brain transduction by intravascularly administered AAV9

CA Maguire, MHW Crommentuijn, D Mu, E Hudry… - Molecular Therapy, 2013 - cell.com
Adeno-associated virus serotype 9 (AAV9) has shown remarkable efficiency in transducing
organs in vivo including the heart, liver, and brain. 1–6 Recently, AAV9 has gained renewed …