Cancer is a complex disease caused by genetic and epigenetic alterations in the control of
cell division. Findings from the field of cancer genomics and epigenomics have increased …

Evolution by natural selection is the conceptual foundation for nearly every branch of biology
and increasingly also for biomedicine and medical research. In cancer biology, evolution …

The description and interpretation of genomic abnormalities in cancer cells have been at the
heart of cancer research for more than a century. With exhaustive sequencing of cancer …

For many years, discoveries about the genetic determinants of cancer appeared to be
having only minor effects on efforts to control the disease in the clinic. Following advances …

The traits (" hallmarks") that the authors highlight in the paper are (1) Cancer cells stimulate
their own growth (self-sufficiency in growth signals);(2) They resist inhibitory signals that …

Cancer is a multifaceted disease characterized by heterogeneous genetic alterations and
cellular metabolism, at the organ, tissue, and cellular level. Key features of cancer …

Cancer has been in existence longer than human beings, and man has been facing the
illness ever since he made his appearance on Earth. Amazingly, the first human cancer …

A core mission of cancer genomics is to comprehensively chart molecular underpinnings of
cancer-driving events and to provide personalized therapeutic strategies. Primarily focused …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …